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. 2023 Nov 3;479(10):2741–2753. doi: 10.1007/s11010-023-04856-3

Table 1.

Aggregate proteins enriched in Alzheimer’s disease brains are also differentially aggregated after MI in mouse brain and heart

Proteins AD/AMC (human brain) MI/Sham (mouse brain) MI/Sham (mouse heart)
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS) 10.00 1.75 3.55
AP-3 complex subunit mu-2 (AP3M2) 10.00 1.71 ND
Actin-related protein 2/3 complex subunit 2 (ARPC2) 10.00 1.51 ND
Carbonyl reductase [NADPH] 3 (CBR3) 180.00 1.60 1.71
Hsp90 co-chaperone Cdc37 (CDC37) 10.00 3.23 60.00
Cytosolic non-specific dipeptidase (CNDP2) 7.00 1.71 120.00
Lambda-crystallin homolog (CRYL1) 20.00 4.00 ND
Ketimine reductase mu-crystallin (CRYM) 2.00 2.20 ND
Eukaryotic translation initiation factor 3 s.u. K (EIF3K) 10.00 3.42 ND
Exocyst complex component 4 (EXOC4) 1.50 1.52 160.00
Guanine nucleotide-binding protein α-13 (GNA13) 2.17 2.70 2.23
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) 20.00 1.71 ND
Adenosine 5'-monophosphoramidase HINT2 (HINT2) 10.00 1.75 11.00
l-lactate dehydrogenase A chain (LDHA) 1.50 27.33 3.78
Mitochondrial carrier homolog 1 (MTCH1) 1.50 4.00 2.75
Nuclear receptor coactivator 7 (NCOA7) 10.00 7.33 ND
Nebulette (NEBL) 1.50 1.83 2.11
Omega-amidase NIT2 (NIT2) 20.00 2.73 10.00
Protein phosphatase 1E (PPM1E) 10.00 1.71 ND
Ribose-phosphate pyrophosphokinase 1 (PRPS1) 10.00 1.94 3.00
E3 ubiquitin-protein ligase RBX1 (RBX1) 10.00 1.50 ND
Receptor expression-enhancing protein 5 (REEP5) 10.00 1.95 40.00
Rho-associated protein kinase 1 (ROCK1) 10.00 2.58 ND
Reticulon-4 (RTN4) 2.00 1.65 2.67
Sec1 family domain-containing protein 1 (SCFD1) 1.50 13.33 100.00
Protein SGT1 homolog (SUGT1) 3.00 1.75 ND
Tripeptidyl-peptidase 1 (TPP1) 10.00 1.61 ND
Vesicle transport protein USE1 (USE1) 10.00 2.58 ND
WD repeat-containing protein 1 (WDR1) 3.00 1.63 2.80

Numbers indicate spectral-count ratios from aggregate proteomics, as indicated. Entries in bold highlight similar changes in AD human brain [6], and mouse post-MI heart and brain