Table 1.
Proteins | AD/AMC (human brain) | MI/Sham (mouse brain) | MI/Sham (mouse heart) |
---|---|---|---|
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS) | 10.00 | 1.75 | 3.55 |
AP-3 complex subunit mu-2 (AP3M2) | 10.00 | 1.71 | ND |
Actin-related protein 2/3 complex subunit 2 (ARPC2) | 10.00 | 1.51 | ND |
Carbonyl reductase [NADPH] 3 (CBR3) | 180.00 | 1.60 | 1.71 |
Hsp90 co-chaperone Cdc37 (CDC37) | 10.00 | 3.23 | 60.00 |
Cytosolic non-specific dipeptidase (CNDP2) | 7.00 | 1.71 | 120.00 |
Lambda-crystallin homolog (CRYL1) | 20.00 | 4.00 | ND |
Ketimine reductase mu-crystallin (CRYM) | 2.00 | 2.20 | ND |
Eukaryotic translation initiation factor 3 s.u. K (EIF3K) | 10.00 | 3.42 | ND |
Exocyst complex component 4 (EXOC4) | 1.50 | 1.52 | 160.00 |
Guanine nucleotide-binding protein α-13 (GNA13) | 2.17 | 2.70 | 2.23 |
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) | 20.00 | 1.71 | ND |
Adenosine 5'-monophosphoramidase HINT2 (HINT2) | 10.00 | 1.75 | 11.00 |
l-lactate dehydrogenase A chain (LDHA) | 1.50 | 27.33 | 3.78 |
Mitochondrial carrier homolog 1 (MTCH1) | 1.50 | 4.00 | 2.75 |
Nuclear receptor coactivator 7 (NCOA7) | 10.00 | 7.33 | ND |
Nebulette (NEBL) | 1.50 | 1.83 | 2.11 |
Omega-amidase NIT2 (NIT2) | 20.00 | 2.73 | 10.00 |
Protein phosphatase 1E (PPM1E) | 10.00 | 1.71 | ND |
Ribose-phosphate pyrophosphokinase 1 (PRPS1) | 10.00 | 1.94 | 3.00 |
E3 ubiquitin-protein ligase RBX1 (RBX1) | 10.00 | 1.50 | ND |
Receptor expression-enhancing protein 5 (REEP5) | 10.00 | 1.95 | 40.00 |
Rho-associated protein kinase 1 (ROCK1) | 10.00 | 2.58 | ND |
Reticulon-4 (RTN4) | 2.00 | 1.65 | 2.67 |
Sec1 family domain-containing protein 1 (SCFD1) | 1.50 | 13.33 | 100.00 |
Protein SGT1 homolog (SUGT1) | 3.00 | 1.75 | ND |
Tripeptidyl-peptidase 1 (TPP1) | 10.00 | 1.61 | ND |
Vesicle transport protein USE1 (USE1) | 10.00 | 2.58 | ND |
WD repeat-containing protein 1 (WDR1) | 3.00 | 1.63 | 2.80 |
Numbers indicate spectral-count ratios from aggregate proteomics, as indicated. Entries in bold highlight similar changes in AD human brain [6], and mouse post-MI heart and brain