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Binding properties of E1A mutants
| Mutant | Bindingc
|
||
|---|---|---|---|
| p300 | Rb | p21 | |
| E1A.928 | +ab | −ab | +b |
| E1A.RG2 | −ab | +ab | +b |
| E1A.dl26-35 | +ab | +ab | −b |
| E1A.dl26-35/928 | +b | −b | −b |
Data obtained from previous work (4,80).
Work described here and unpublished results of E1A interactions with p300 and Rb in HCT116 cells (D. Chattopadhyay).
+, positive for binding to a cellular protein; −, negative for binding to a cellular protein.
