Table 1.
Study characteristics.
| Population | Study | Participant (N) | Scan (N) | Age (year) | Sex/female | CU | AD | MCI | proxy-AD |
|---|---|---|---|---|---|---|---|---|---|
| MCI/AD | ADNI & BLSA | 1534 | 7019 | 73.45 (54.27, 93.00) | 888/58% | 0 | 424 | 1110 | NA |
| General | UKBB | 39,575 | 40,981 | 64.12 (44.56, 82.27) | 18,625/47% | 39,574b | 1 | NA | 10,189c |
| CU | ADNI & BLSA | 1658 | 6143 | 65.75 (22.00, 80.00) | 939/57% | 1658 | 0 | 0 | NA |
| CU with a family risk | PREVENT-AD | 343 | 1215 | 63.63 (55.13, 84.22) | 243/71% | 343a | NA | NA | 343a |
We present the age with the mean, min, and max in each population. The definition of cognitively unimpaired (CU)a in PREVENT-AD, asymptomatic participantsb in UKBB, and proxy-ADc in UKBB are detailed as (a) Participants (proxy-AD and CU with a family risk) from the PREVENT-AD study were recruited with the following criteria: (i) being cognitively normal, (ii) having a family history of AD, (iii) aging within 15 years from the age of disease onset of their youngest relative, and (iv) no history of neurological or psychiatric diseases; (b) The UKBB participants (the general population) represent a general population with healthy Aging and diseases (not AD, specifically). We excluded those diagnosed with all sources of dementia (G30 in ICD-10 diagnoses, see below). However, these asymptomatic participants might have diagnoses of other illnesses or comorbidities based on ICD-10; (c) Participants with proxy-AD in UKBB are defined by a family history of AD with the following criteria: (i) illnesses_of_father_f20107 and (ii) illnesses_of_mother_f20110.