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. 2024 Oct 5;8:225. doi: 10.1038/s41698-024-00680-0

Fig. 1. Transcriptomic intratumor heterogeneity (RNA-ITH) in NSCLC.

Fig. 1

a Overview of the study. Multiregional RNA-seq data from two cohorts were used in this study. The main findings were identified in the TRACERxC1 cohort and confirmed in the TRACERxC2, TRACERxLUAD, and MDAMPLC cohorts. b, c Violin plot showing that RNA-ITH is lower than intertumor heterogeneity in both b TRACERxC1 and c MDAMPLC cohorts. d, e Patient-specific RNA-ITH in the d TRACERxC1 and e MDAMPLC cohorts. Each dot represents the paired tumor region from the patient. The curve indicates the patient-specific RNA-ITH, calculated by averaging the RNA-ITH of all region pairs. Significance is determined by the Wilcoxon Rank-Sum one-sided test.