Table 1.

Nine public signatures improved by multiregional RNA-seq data

Cohort		TRACERxC1			MDAMPLC	TRACERxC1			MDAMPLC	TRACERxC1			MDAMPLC
Method	Function	HR	p-Value	C-index	C-index	HR	p-Value	C-index	C-index	HR	p-Value	C-index	C-index
Signature		Boutros et al., 2008 (N  =  5)				Krzystanek et al., 2016 (N  =  6)				Bianchi et al., 2007 (N  =  10)
Transformed gene expression (Method 1)	Avg.	2.588	0.023	0.673	0.481	2.787	0.065	0.627	0.505	1.927	0.178	0.6	0.542
	Max.	2.541	0.018	0.693	0.486	2.824	0.05	0.625	0.557	2.293	0.076	0.645	0.58
	Min.	2.529	0.037	0.67	0.476	2.419	0.089	0.622	0.495	1.507	0.396	0.578	0.481
	Adj.	2.304	0.012	0.706	0.618	1.998	0.018	0.685	0.608	2.071	0.035	0.667	0.575
	Rev.	1.549	0.315	0.579	0.439	1.114	0.776	0.537	0.462	0.961	0.923	0.486	0.458
Region-specific (Method 2)	Avg.	2.588	0.023	0.673	0.481	2.787	0.065	0.627	0.505	1.927	0.178	0.6	0.542
	Max.	2.624	0.008	0.698	0.509	3.021	0.045	0.628	0.524	1.981	0.142	0.62	0.557
	Min.	2.289	0.073	0.651	0.448	2.166	0.129	0.617	0.476	1.723	0.254	0.594	0.486
Signature		Kratz et al., 2012 (N = 11)				Zhu et al., 2010 (N = 15)				Garber et al., 2001 (N = 24)
Transformed gene expression (Method 1)	Avg.	1.926	0.14	0.59	0.557	1.638	0.294	0.562	0.547	1.813	0.09	0.638	0.5
	Max.	2.012	0.095	0.603	0.599	2.563	0.034	0.641	0.59	2.284	0.011	0.669	0.519
	Min.	1.861	0.141	0.613	0.472	0.862	0.734	0.456	0.538	1.281	0.471	0.576	0.434
	Adj.	2.031	0.035	0.646	0.608	2.586	0.021	0.657	0.58	2.404	0.004	0.708	0.538
	Rev.	1.281	0.558	0.518	0.472	0.756	0.462	0.41	0.538	0.919	0.77	0.492	0.467
Region-specific score (Method 2)	Avg.	1.926	0.14	0.59	0.557	1.638	0.294	0.562	0.547	1.813	0.09	0.638	0.5
	Max.	2.183	0.054	0.629	0.59	2.231	0.079	0.621	0.594	2.023	0.041	0.646	0.519
	Min.	1.587	0.307	0.558	0.467	1.083	0.855	0.496	0.533	1.485	0.243	0.6	0.439
Signature		Wistuba et al., 2013 (N = 30)				Raz et al., 2008 (N = 54)				Beer et al., 2002 (N = 92)
Transformed gene expression (Method 1)	Avg.	2.086	0.006	0.696	0.533	1.386	0.15	0.581	0.514	1.163	0.258	0.591	0.524
	Max.	2.256	0.003	0.711	0.59	1.622	0.015	0.654	0.58	1.301	0.045	0.63	0.552
	Min.	1.838	0.019	0.679	0.481	1.055	0.79	0.502	0.439	1.018	0.876	0.519	0.443
	Adj.	1.24	0.013	0.714	0.618	1.245	0.017	0.693	0.594	1.094	0.013	0.711	0.575
	Rev.	0.973	0.834	0.481	0.425	0.926	0.415	0.385	0.448	0.943	0.102	0.341	0.462
Region-specific score (Method 2)	Avg.	2.086	0.006	0.696	0.533	1.386	0.15	0.581	0.514	1.163	0.258	0.591	0.524
	Max.	2.08	0.004	0.7	0.599	1.354	0.127	0.598	0.542	1.286	0.062	0.637	0.533
	Min.	1.966	0.013	0.683	0.476	1.209	0.367	0.549	0.472	1.075	0.533	0.564	0.462