Table 2.

Summary of miRNAs that are dysregulated in PD and their downstream targets

Study	miRNAs	Dysregulation	Downstream targets	Effect of miRNA regulation on microglia (MG)
Yao et al.84.	miR-124	Downregulated	p62, p38, p-p65, MEKK3	Reduces inflammation in MG in PD with p62 and p38. In SH-SY5Y human neuroblastoma cells activated with MG, p62 knockdown prevents cell apoptosis and death
Ren et al.24.	miR-195	Downregulated	ROCK1	RCK1 is responsible for MG activation, by negatively regulating it
Li et al.85.	miR-let-7a	Downregulated	STAT3	Inhibit BV-2 MG activation and reduce pro-inflammatory agents produced by α-syn
Zhang et al.86	miR-150	Downregulated	AKT3	Inhibit the release of proinflammatory cytokines including TNF-α, IL-1β and IL-6
Feng et al.87.	miR-330	Upregulated	SHIP1	MG SHIP1 target protein negatively controls the activity of NF-κB
Runxiao Lv146	miR155-5p	Downregulated	SHIP1	Suppress the activity of NF-κB
He et al.88	miR-7116-5p	Downregulated	TNF-α	Inhibition of the production of TNF-α and the activation of MG.
Zhou et al.90.	miR-7	Downregulated	NLRP3	Inhibits the activation of NLRP3 inflammasomes in MG
Sun et al.91.	miR-190	Downregulated	NLRP3	Inhibit the release of pro-inflammatory factors, including TNF-α, TGF-β1, iNOS, and IL-6
Wang et al.92.	miR-29c	Downregulated	NFAT5	Overexpression suppresses pro-inflammatory cytokine release, along with NF-κB and TXNIP/NLRP3 inflammasome activation
Li et al.93.	miR-30e	Downregulated	NLRP3	Inhibition of NLRP3 mRNA and protein expression