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. 2024 Oct 6;10:88. doi: 10.1038/s41523-024-00697-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Reverse-phase phosphoprotein analysis (RPPA) was performed on laser-captured, fresh frozen tumor that was split into two groups for comparison: PEPI = 0 (blue, N = 9) tumors that responded to treatment, and PEPI > 0 (orange, N = 45) tumors that did not. Tumors came from patients in both arms. Presented phosphoproteins were significantly (p < 0.1) differentially expressed by the Empirical Bayes moderated t-test. a Dumbbell plot of the mean log2 baseline expression for patients with PEPI = 0 and PEPI > 0 for each significant phosphoprotein. b Dumbbell plot of the mean log2 change in expression among patients with PEPI = 0 and PEPI > 0 for each significant phosphoprotein.