Table 2.
Surgical and Ki67 results
| Combo arm (N = 33) | Fulv arm (N = 26) | Total (N = 59) | |
|---|---|---|---|
| Surgerya | |||
| No | 2 (6.1%) | 1 (3.8%) | 3 (5.1%) |
| Yes | 31 (93.9%) | 25 (96.2%) | 56 (94.9%) |
| PEPI Score | |||
| >0 | 25 (75.8%) | 24 (92.3%) | 49 (83.1%) |
| 0 | 8 (24.2%) | 2 (7.7%) | 10 (16.9%) |
| Ki67 at W5b | |||
| N | 26 | 24 | 50 |
| ≤10% | 18 (69.2%) | 20 (83.3%) | 38 (76.0%) |
| Ki67 at surgeryb | |||
| N | 26 | 22 | 48 |
| ≤10% | 19 (73.1%) | 17 (77.3%) | 36 (75.0%) |
| Change in Ki67 BL—W5 | |||
| N | 26 | 22 | 48 |
| High BL, High W5 | 8 (30.8%) | 4 (18.2%) | 12 (25.0%) |
| High BL, Low W5c | 11 (42.3%) | 9 (40.9%) | 20 (41.7%) |
| Low BL, Low W5 | 7 (26.9%) | 9 (40.9%) | 16 (33.3%) |
| Change in Ki67 BL—surgery | |||
| N | 25 | 20 | 45 |
| High BL, high surgery | 7 (28.0%) | 4 (20.0%) | 11 (24.4%) |
| High BL, low surgery | 11 (44.0%) | 7 (35.0%) | 18 (40.0%) |
| Low BL, high surgery | 0 (0.0%) | 1 (5.0%) | 1 (2.2%) |
| Low BL, low surgery | 7 (28.0%) | 8 (40.0%) | 15 (33.3%) |
N is provided for variables with less than 59 variables, and the percentage shown is out of the non-missing total.
a“Yes” indicates patients who had surgery during the study, and “No” indicates patients who did not have surgery during the study. Three patients did not have surgery: one insurance-related, and two received additional therapy prior to surgery due to the physician’s decision.
b“≤10%” indicates patients who had low Ki67 (≤10%) as measured by IHC at each time point. High Ki67 is defined as >10%.
cThe high BL, low W5 group are designated as responders by Ki67.