Table 4.
Univariate associations with PEPI Score (PEPI = 0, PEPI > 0)
| Univariate predictors | N | OR | 95% CI | p-value |
|---|---|---|---|---|
| Age at consent (years) | 59 | 1.05 | 0.99, 1.13 | 0.13 |
| Lab AR (%) | ||||
| Baseline Lab AR (%) | 55 | 1 | 0.98, 1.03 | 0.96 |
| Week 5 Lab AR (%) | 51 | 1 | 0.97, 1.02 | 0.71 |
| Surgery Lab AR (%) | 50 | 0.99 | 0.97, 1.01 | 0.34 |
| Lab ER (%) | ||||
| Baseline Lab ER (%) | 55 | 0.99 | 0.97, 1.01 | 0.47 |
| Week 5 Lab ER (%) | 51 | 0.99 | 0.96, 1.01 | 0.3 |
| Surgery Lab ER (%)a | 50 | 0.99 | 0.97, 1.01 | 0.34 |
| Ki67 (%) | ||||
| Baseline Ki67 (%) | 50 | 0.9 | 0.79, 0.98 | 0.004 |
| Week 5 Ki67 (%) | 49 | 0.62 | 0.29, 0.95 | 0.005 |
| Histology | 56 | 0.059 | ||
| Invasive ductal carcinoma (IDC) | 45 | – | – | |
| Invasive lobular carcinoma (ILC) | 11 | 4.57 | 0.94, 21.97 |
Univariate logistic regression models with PEPI score (PEPI = 0 vs reference: PEPI > 1) as the outcome are presented with profile likelihood CIs and likelihood ratio test (LRT) p-values. Odds ratios above one indicate increases in the odds of response (PEPI = 0), and odds ratios below one indicate decreases in the odds of response.
OR odds ratio, CI confidence interval.
aWhile Lab ER at the time of surgery was included in the PEPI score, other components of PEPI score dictated whether patients were 0 or non-zero.