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. 2024 Oct 5;7:1268. doi: 10.1038/s42003-024-06944-6

Fig. 8. Basal miRNA expression in healthy tissues and predicted small molecule drugs.

Fig. 8

a Heatmap presenting miRNA expression levels as z-scores across various healthy tissues, sourced from the miRNA Tissue Atlas. b Heatmap illustrating the mode of action and enriched drug indicators for predicted small molecule drugs targeting the miRNAs, as determined by sChemNET. Color intensity represents −log10(adj. p-value). c Upset plot revealing specific predicted small molecule drugs that target the miRNA signature associated with Small-for-Gestational-Age (SGA) in spaceflight. The drugs are in common with 5 or more of the 13 miRNAs. Notably, two small molecule drugs, triamcinolone and perfluorodecalin, are shared among all the identified miRNAs. All predicted small molecule drugs can be found in Supplementary Fig. 11 and Supplementary Data 3.