Table 4.
Univariate and multivariate logistic regression analyses of factors associated with irAEs.
| Clinical variables | Crude Odds 95% CI | Adjusted a Odds 95% CI |
|---|---|---|
| Age | ||
| <64 | REF | —— |
| ≥ 65 | 1.216 (0.572-2.586) | —— |
| Sex | ||
| Female | REF | REF |
| Male | 1.904 (0.847-4.279) | 1.205 (0.40-3.156) |
| Smoking | ||
| No | REF | REF |
| Yes | 1.627 (0.781-3.390) | 2.074 (0.821-5.241) |
| ICI type | ||
| PD-1 | REF | —— |
| PD-L1 | 1.278 (0.566-2.884) | —— |
| BMI | ||
| Normal weight | REF | REF |
| Underweight | 0.505 (0.102-2.500) | 0.237 (0.042-1.347) |
| Overweight and Obese | 2.409 (1.101-5.271) | 2.737 (1.147-6.533) |
| Performance Status | ||
| 0 | REF | —— |
| 1 | 1.600 (0530-4.832) | —— |
| 2 | 1.784 (0.616-5.169) | —— |
| SMI | ||
| No sarcopenia | REF | REF |
| Sarcopenia | 2.543 (1.137-5.688) | 2.635 (1.099-6.317) |
| Sarcopenia and BMI | ||
| No sarcopenia | REF | REF |
| Sarcopenia and BMI ≤ 18.5 |
1.013 (0.184-5.590) | 0.573 (0.092-3.554) |
| Sarcopenia and 18.5<BMI ≤ 24.9 |
1.899 (0.759-4.752) | 1.882 (0.724-4.893) |
| Sarcopenia and BMI≥25 |
5.157 (1.863-14.278) | 5.502 (1.861-16.262) |
| PD-L1 expression | ||
| <1% | REF | REF |
| ≥ 1% | 2.411 (1.123-5.176) | 3.075 (1.322-7.149) |
CI, confidence interval; OR, odds ratio.
a
Variables with p-values <0.2 in the univariate analysis were included in the multivariate analysis; The variables SMI and BMI were removed from the multivariate logistic analysis of Sarcopenia and BMI.
Bold indicates statistically significant, P < 0.05.