Table 6.
Univariate and multivariate logistic regression analyses of factors associated with irAEs after propensity score matching.
| Clinical variables | Crude Odds 95% CI | Adjusteda Odds 95% CI |
|---|---|---|
| Age | ||
| <64 | REF | REF |
| ≥ 65 | 2.040 (0.688-6.045) | 1.634 (0.444-6.007) |
| Sex | ||
| Female | REF | REF |
| Male | 2.586 (0.747-8.949) | 2.361 (0.518-10.753) |
| Smoking | ||
| No | REF | REF |
| Yes | 2.486 (0.834-7.411) | 1.493 (0.391-5.703) |
| ICI type | ||
| PD-1 | REF | —— |
| PD-L1 | 1.120 (0.339-3.698) | —— |
| BMI | ||
| Normal weight | REF | —— |
| Underweight | 0.658 (0.233-3.752) | —— |
| Overweight and Obese | 1.790 (0.587-5.464) | —— |
| Performance Status | ||
| 0 1 2 |
REF 0.921 (0.217-3.917) 1.000 (0.242-4.138) |
—— —— —— |
| SMI | ||
| No sarcopenia | REF | REF |
| Sarcopenia | 4.060 (1.261-13.072) | 5.674 (1.506-21.380) |
| Sarcopenia and BMI | ||
| No sarcopenia | REF | REF |
| Sarcopenia and BMI ≤ 18.5 |
1.106 (0.149-6.423) | 1.701 (0.145-4.524) |
| Sarcopenia and 18.5<BMI ≤ 24.9 |
3.867 (1.049-14.248) | 5.025 (1.201-24.465) |
| Sarcopenia and BMI≥25 |
6.960 (1.523-31.811) | 8.843 (1.625-36.220) |
| PD-L1 expression | ||
| <1% | REF | REF |
| ≥ 1% | 2.368 (0.804-6.974) | 4.037 (1.089-14.958) |
Bold indicates statistically significant, P < 0.05.