TABLE 1.
Correlation of the membrane-binding ability and multimerization potentials of subdomains located in the HIV-1 gp41 cytoplasmic tail
| Segment | Membrane associationa | Multimerization potentialb |
|---|---|---|
| 706–856 | + | Multimer |
| 706–752 | − | Monomer |
| 706–795 | + | Multimer |
| 760–856 | + | Multimer |
| 816–856 | + | Multimer |
| 760–795 | + | Multimer |
| 786–813 | + | ND |
| 816–844 | − | Monomer |
| 760–775 | + | Low-ordered multimer and monomer |
| 786–805 | + | ND |
a
The membrane association ability of subdomains in the gp41 cytoplasmic tail was assessed by membrane flotation assay as described in the text.
b
The results for the multimerization potential of the cytoplasmic tail subdomains, as assessed by gel filtration analysis of the maltose-binding protein fused to these subdomains, were extracted from a previous paper (39). ND, not determined.