Table 2.
Results of DMA and TMA for diabetic foot outcomes in different treatments measure.
| Outcome | Studies (n) | Participants (n) | DMA | NMA |
|---|---|---|---|---|
| Effect Estimate (95% CI) | Effect Estimate (95% CI) | |||
| Complete wound healing | 49 | 4010 | ||
| Standard vs PRP HBOT vs PRP Standard vs NPWT UD+NPWT vs NPWT PRP+NPWT vs NPWT Standard vs HBOT Standard vs TOT Standard vs UD Standard vs ADM Standard vs Scs Scs+PRP vs Scs Scs+PRP vs Standard |
14 1 2 3 5 8 5 2 6 5 2 2 |
1010 40 390 170 439 515 461 160 672 207 34 29 |
0.15 (0.069, 0.29)
0.35 (0.021, 5.7) 0.22 (0.038, 1.1) 2.9 (0.62, 15.0) 3.5 (1.2, 10.0) 0.37 (0.14, 0.94) 0.25 (0.078, 0.69) 0.29 (0.050, 1.7) 0.19 (0.070, 0.50) 0.12 (0.024, 0.56) 2.3 (0.23, 23.0) 3.6 (0.033, 42.0) |
0.15(0.070, 0.28)
0.39 (0.13, 1.2) 0.22 (0.038, 1.1) 2.9 (0.61, 15.0) 3.5 (1.2, 10.0) 0.37(0.14, 0.92) 0.25 (0.078, 0.69) 0.29 (0.050, 1.7) 0.19 (0.070, 0.50) 0.10 (0.022, 0.40) 2.2 (0.29, 18.0) 22.0 (2.5, 23.0) |
| Reduced ulcer area | 19 | 1626 | ||
| Standard vs PRP Standard vs NPWT UD+NPWT vs NPWT PRP+NPWT vs NPWT Standard vs HBOT Standard vs TOT Standard vs UD Standard vs ADM Standard vs Scs Scs+PRP vs Scs Scs+PRP vs Standard |
6 3 2 1 1 1 1 1 3 1 1 |
453 378 223 110 104 73 100 85 90 21 17 |
-4.0(-9.4, 1.3) -6.2(-14.0, 1.3) 7.1(-2.3, 17.0) 1.1(-12.0, 14.0) -0.11 (-13.0, 13.0) -0.99(-14.0, 12.0) -5.2 (-18, 7.9) 1.1 (-12.0, 14.0) 0.037(-7.7, 7.7) -0.045 (-13.0, 13.0) 4.9(-8.7, 18.0) |
-4.0(-9.4, 1.4) -6.2(-14.0, 1.3) 7.1(-2.3, 17.0) 1.1(-12.0, 14.0) -0.094 (-13.0, 13.0) -1.0(-14.0, 12.0) -5.2 (-18, 7.9) (-12.0, 14.0) -0.025(-7.7, 7.6) 2.3 (-9,7, 14.0) 2.4 (-9.7, 14.0) |
| Time to complete healing | 15 | 1135 | ||
| Standard vs PRP Standard vs NPWT UD+NPWT vs NPWT PRP+NPWT vs NPWT |
6 2 3 4 |
413 110 273 339 |
3.0(2.2, 3.7)
3.8(2.6, 4.9) -2.1(-3, -1.2) -1.3(-2.1, -0.54) |
3.0(2.2, 3.7)
3.8(2.6, 4.9) -2.1(-3, -1.2) -1.3(-2.1, -0.54) |
| Amputation rate | 17 | 1706 | ||
| Standard vs PRP Standard vs NPWT UD+NPWT vs NPWT PRP+NPWT vs NPWT Standard vs HBOT Standard vs TOT Standard vs Scs |
5 3 1 1 6 2 1 |
408 464 70 110 439 195 20 |
6.8(2.2, 41.0)
1.2(0.41, 3.7) — — 1.9(0.79, 4.8) 2.5(0.29, 33.0) — |
7.0(2.2, 41.0)
1.2(0.40, 3.8) — — 1.9(0.79, 4.8) 2.5(0.29, 35.0) — |
| Adverse events | 27 | 2755 | ||
| Standard vs PRP Standard vs NPWT UD+NPWT vs NPWT PRP+NPWT vs NPWT Standard vs HBOT Standard vs TOT Standard vs UD Standard vs ADM Standard vs Scs |
5 3 3 2 4 3 1 5 1 |
367 445 170 208 347 341 100 672 105 |
3.5 (1.4, 8.9)
1.4 (0.44, 5.6) 0.098 (0.0082, 0.73) 0.18 (0.031, 0.90) 1.1(0.42, 3.0) 1.5 (0.54, 4.2) 1.0 (0.13, 7.8) 1.2 (0.47, 3.0) 3.4 (0.34, 44) |
3.5 (1.4, 8.9)
1.4 (0.44, 5.7) 0.099 (0.0082, 0.73) 0.19(0.032, 0.91) 1.1(0.42, 3.0) 1.5 (0.54, 4.2) 0.99(0.13, 7.9) 1.1(0.46, 3.0) 3.3 (0.34, 43) |
The bold values indicate statistical significance.