Table 2.
Targets of gene therapy.
| Relevant type | Vector type | Function | Reference |
|---|---|---|---|
| Calcium Release–Activated Calcium Channel 3 | Adenovirus | Reduces the inflammatory and auto-immune responses, decreases the activity of mature osteoclasts | (133) |
| TNF alpha-induced protein 3 | adeno-associated virus 6 | Relieves the arthritis symptoms by inhibiting NLRP3, caspase-1, and IL-1β | (134) |
| Tumor necrosis factor-alpha-induced protein 8-like 2 | Lentivirus | Attenuates collagen-induced joint severity by inhibiting the infiltration of macrophages and MDSCs | (135) |
| Caspase recruitment domain protein 6 | Adeno-associated virus | Attenuates the severity of arthritis, improved histopathological damage, and hindered the bone erosion in collagen-induced arthritis (CIA) mice. | (136) |
| Aquaporin 1 | Lentivirus | Affects the proliferation, migration and invasion of MH7A cells by Wnt/β-catenin signaling pathway, | (137) |
| β-arrestin-2 | Adenovirus | Ameliorates ankle inflammation in CIA mice via NF-κB/NLRP3 inflammasome | (22) |