Fig. 3.

Impact of ACF and effects of RDN on selected parameters of sympathetic nervous system in left ventricle. a Plasma norepinephrine (NE). b NE content in kidney. c NE content in left ventricle (LV). d Biosynthesis of NE—protein expression of tyrosine hydroxylase (TH). e Preganglionic NE transport—protein expression of NE transporter (NET). f NE transport to cardiomyocyte—protein expression of organic cation transporter 3 (OCT3). g Degradation of NE—protein expression of monoamine oxidase A (MAO-A). h Production of reactive oxygen species (ROS) by MAO-A. i Gene expression of beta-1 adrenergic receptor (Adrb1). j Gene expression of choline muscarinic receptor type 2 (Chrm2). k Gene expression of acetylcholinesterase (Ache). l Neprilysin activity measured in kidney. N = 8 in sham/intact, N = 8 in ACF/intact, N = 8 in ACF/RDN