FIG. 8.

Inflammatory responses induced by RM461 and RQ461 following footpad inoculation. Tissues were harvested from an inoculated mouse foot 48 h after inoculation with RQ461 or RM461 (10⁶ PFU in 3 μl of growth medium), formalin fixed, and decalcified; after embedding in paraffin, 5-μm sections were cut and stained with hematoxylin and eosin. (A) RQ461. (B) RM461. (C) RQ461. (D) RM461. The dorsal, internal, and ventral areas are denoted by white, grey, and black bars, respectively, on the sides of panels A and B. Areas boxed in panels A and B are magnified in panels C and D, respectively.