The binding affinity (kcal mol⁻¹) for the three promising compounds 1a, 8a and 13a and the native ligands in the CDK2 and GSK3β kinase domain.

Compound	Binding affinity (kcal mol−1) CDK2	Binding affinity (kcal mol−1) GSK3β
1a	−6.4	−5.5
8a	−8.2	−7.8
13a	−8.6	−8.0
AZD5438	−8.6	—
2WF	—	−8.6