Figure 3: Key legal events in the patent lifecycles of GLP-1 receptor agonists.

This figure shows the distribution of key legal events associated with the patent life cycle (priority date, filing date, granting date, and expiration date) for each patent in the cohort relative to the corresponding product’s approval date. Boxes represent the interquartile range (IQR) with vertical lines in each box depicting the median, and whiskers extend in either direction from the first and third quartiles by up to 1.5-times the IQR. There were 186 total patents listed on the 10 products in the cohort, and each of the 4 plots depicts the relevant legal event for all patents in the cohort. Of note, this figure excludes patents (n=7) that were removed from the Orange Book prior to expiration since these patents do not contribute to expected periods of patent protection (primary endpoint).