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. Author manuscript; available in PMC: 2024 Oct 7.
Published in final edited form as: J Immunol. 2016 Apr 22;196(11):4614–4621. doi: 10.4049/jimmunol.1600082

FIGURE 3.

FIGURE 3.

CD4+ T cells are not required during booster immunization with MenC for augmented MCPS-specific IgG responses. BALB/c mice (7 per group) were immunized i.p. with 2 × 108 CFU/mouse of intact heat-inactivated MenC (day 0) and boosted i.p. with the same dose of MenC on day 21. Depleting anti-CD4 mAb (clone GK1.5, 0.5 mg/mouse) or control rat IgG (0.5 mg/mouse) were injected on either day −1 or day 20. Serum titers of MCPS-specific IgG were determined by ELISA (*p ≤ 0.05) (significance between secondary titers of rat IgG-injected versus anti-CD4 mAb-injected groups).