Table 2 .

Top-ranked altered pathways (NCI-Nature pathway database) comparing the differences between mono-cultured and CAF co-cultured SUM149 cells.

Top-ranked pathways	P-value
E-cadherin signaling in the nascent adherens junction	2.01E-07
HIF-1-alpha transcription factor network	5.06E-07
RAC1 signaling pathway	0.000008934
Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.000004479
AP-1 transcription factor network	0.0000255
ErbB1 downstream signaling	0.00004934
Validated targets of C-MYC transcriptional activation	0.00002596
a6b1 and a6b4 Integrin signaling	0.00004988
VEGFR1 specific signals	0.00003069
Validated targets of C-MYC transcriptional repression	0.0002151