| References |
Study Design |
Population |
Intervention |
Comparator |
Outcome Measures |
Key Findings |
Risk of Bias |
Limitations |
Conclusion |
| Stosich et al. [18] |
Experimental |
Human adults, stem cells |
Adipose tissue engineering |
Traditional grafts/flaps |
Scar quality, integration, immune response |
High tissue integration, minimal fibrosis |
Low |
Short follow-up, small sample size |
Promising for reconstructive applications |
| Ochi et al. [19] |
RCT |
Patients with cartilage defects |
Tissue-engineered cartilage |
Traditional cartilage repair |
Pain relief, cartilage quality |
Significant cartilage regeneration, pain relief |
Low |
Limited to specific cartilage defect types |
Effective for articular cartilage repair |
| Alonzo et al. [15] |
Review |
N/A |
Various tissue engineering techniques |
N/A |
Biocompatibility, structural support |
High biocompatibility, effective structural support |
High |
Review limited to published studies |
Significant potential in bone tissue engineering |
| Gjerde et al. [20] |
Experimental |
Patients with mandibular atrophy |
Cell therapy-induced bone regeneration |
N/A |
Bone formation, patient satisfaction |
Significant new bone formation, high patient satisfaction |
Low |
Small sample size, single-site study |
Successful bone formation, further trials needed |
| Tavelli et al. [21] |
Review |
Patients with periodontal defects |
Tissue engineering strategies |
Traditional periodontal techniques |
Bone regeneration, pocket depth reduction |
Effective bone regeneration, high patient satisfaction |
High |
Limited to periodontal applications |
Effective for periodontal reconstruction |
| Muylaert et al. [16] |
Experimental |
Patients needing vascular scaffolds |
Bioactivating cell-free vascular scaffolds |
Traditional vascular grafts |
Neotissue formation, vascularization |
Enhanced neotissue formation, controlled scaffold degradation |
Low |
Early-stage study, limited clinical trials |
Promising for vascular tissue engineering |
| Tan et al. [22] |
Experimental |
Patients needing penile reconstruction |
Complete penile scaffold |
Traditional penile reconstruction |
Biocompatibility, penile function restoration |
High biocompatibility, successful penile function restoration |
Low |
Early-stage study, limited clinical trials |
Promising for penile reconstruction |
| Jeon et al. [23] |
Review |
Patients with osteochondral defects |
Multiphasic osteochondral tissue engineering |
Traditional osteochondral repair |
Osteochondral regeneration, mechanical properties |
Effective osteochondral regeneration, appropriate mechanical properties |
High |
Limited to specific osteochondral defects |
Effective for osteochondral tissue engineering |
| Kwon et al. [24] |
Review |
Patients needing stem cell therapy |
Stem cell therapeutics |
Traditional stem cell therapy |
Stem cell viability, differentiation |
Enhanced stem cell viability, positive regenerative outcomes |
High |
Need for standardized protocols |
Significant potential for stem cell therapeutics |
| Feinberg et al. [17] |
Review |
Patients needing maxillofacial reconstruction |
Tissue engineering in oral/maxillofacial reconstruction |
Traditional maxillofacial reconstruction |
Scaffold integration, functional outcomes |
High biocompatibility, successful scaffold integration |
High |
Limited to maxillofacial applications |
Promising for oral/maxillofacial reconstruction |
| DiMuzio et al. [25] |
Experimental |
Patients needing vascular grafts |
Adipose-derived stem cells for vascular bypass |
Traditional vascular bypass grafts |
Cell availability, scaffold integration |
Successful differentiation, promising functional outcomes |
Low |
Early-stage study, limited clinical trials |
Promising for vascular tissue engineering |
| Sterodimas et al. [6] |
Review |
Patients needing plastic/reconstructive surgery |
Adipose-derived stem cells in plastic surgery |
Traditional plastic surgery techniques |
ADSC viability, regenerative outcomes |
High ADSC viability, effective scaffold integration |
High |
Need for standardized protocols |
Promising for plastic/reconstructive surgery |
| Roddy et al. [26] |
Review |
Patients with bone defects |
Tissue engineering for critical-sized bone defects |
Traditional bone defect treatments |
Bone regeneration, graft integration |
Effective bone regeneration, improved clinical outcomes |
High |
Limited to bone defects |
Enhances treatment of critical-sized bone defects |
| Miron et al. [27] |
RCT |
Patients with periodontal defects |
Platelet-rich fibrin for periodontal defects |
Traditional periodontal defect treatments |
Periodontal regeneration, bone fill |
Significant periodontal regeneration, enhanced bone fill |
Low |
Small sample size, single-site study |
Effective for periodontal defects |
