Figure 1. IL-17B attenuates IMQ-induced disease progression in mice with lupus.

(A) Splenic images, (B) spleen weights, (C) serum levels of anti-dsDNA antibodies, (D) H&E staining of kidney, and (E) renal IgG and IgM deposition in WT or IL-17B–KO mice treated with IMQ. (F) Splenic images, (G) spleen weights, (H) serum levels of anti-dsDNA antibodies, (I) H&E staining of kidney, and (J) renal IgG and IgM deposition in IMQ-induced WT mice treated with vehicle or rmIL-17B. Scale bars: 100 μm. The data are shown as the mean ± SEM and are representative of 3 independent experiments (n = 6 mice/group). *P < 0.05, **P < 0.01 by 2-tailed Student’s t test.