Table 1. Baseline characteristics of patients with intrahepatic cholestasis: comparative analysis with and without jaundice.
| Characteristics | Cholestatic jaundice | Cholestatic non-jaundice | P value |
|---|---|---|---|
| n | 118 | 534 | |
| Gender, n (%) | 0.710a | ||
| Male | 63 (53.4%) | 275 (51.5%) | |
| Female | 55 (46.6%) | 259 (48.5%) | |
| Age, median (IQR) | 58 (51, 67) | 59 (54, 67) | 0.272b |
| Type of cholestasis, n (%) | 0.684a | ||
| Chronic | 61 (51.7%) | 265 (49.6%) | |
| Acute | 57 (48.3%) | 269 (50.4%) | |
| apoA1, median (IQR) | 0.71 (0.54, 0.87) | 1.07 (0.84, 1.37) | <0.001b |
| apoB, median (IQR) | 1.10 (0.90, 1.43) | 0.95 (0.81, 1.16) | <0.001b |
| TC, median (IQR) | 5.47 (4.26, 7.44) | 4.66 (3.99, 5.61) | <0.001b |
| TG, median (IQR) | 1.50 (1.16, 2.02) | 1.16 (0.86, 1.60) | <0.001b |
| HDL-C, median (IQR) | 0.59 (0.45, 0.86) | 1.07 (0.79, 1.41) | <0.001b |
| GGT, median (IQR) | 501.0 (332.8, 818.5) | 310.5 (226.3, 444.8) | <0.001b |
| ALP, median (IQR) | 400.0 (285.3, 619.3) | 251.0 (200.0, 339.0) | <0.001b |
| TB, median (IQR) | 104.3 (73.4, 151.2) | 10.9 (6.9, 18.8) | <0.001b |
| DB, median (IQR) | 70.9 (49.1, 108.8) | 5.4 (3.0, 10.8) | <0.001b |
| TBA, median (IQR) | 75.4 (36.1, 145.1) | 7.9 (4.0, 18.3) | <0.001b |
| AST, median (IQR) | 149.0 (94.5, 268.0) | 52.0 (32.3, 83.8) | <0.001b |
| ALT, median (IQR) | 82.5 (49.0, 157.8) | 36.0 (22.0, 59.8) | <0.001b |
| LDL-C(D), median (IQR) | 2.99 (2.41, 3.49) | 3.00 (2.44, 3.72) | 0.603b |
| LDL-C(F), median (IQR) | 3.92 (2.82, 5.77) | 2.86 (2.34, 3.67) | <0.001b |
| NH-C/B ratio, median (IQR) | 3.99 (3.47, 4.61) | 3.63 (3.38, 3.88) | <0.001b |
| Lipid testing, n (%) | <0.001a | ||
| Accurate | 75 (63.6%) | 482 (90.3%) | |
| Inaccurate | 43 (36.4%) | 52 (9.7%) |
Notes:
a
Denotes the use of the chi-square test (Chisq test).
b
Indicates the application of the Wilcoxon test.
Abbreviations: apoA1, Apolipoprotein A1; apoB, Apolipoprotein B; TC, Total cholesterol; TG, Triglycerides; HDL-C, High-density lipoprotein cholesterol; GGT, Gamma-glutamyl transferase; ALP, Alkaline phosphatase; TB, Total bilirubin; DB, Direct bilirubin; IB, Indirect bilirubin; TBA, Total bile acids; AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; LDL-C(D), Low-density lipoprotein cholesterol (the homogeneous method); LDL-C(F), Low-density lipoprotein cholesterol (calculated using the Friedewald formula); NH-C/B ratio, the ratio of non-HDL-C and APOB ((TC-HDL-C)/APOB).