FIG 6.

Five-year recurrence rates by CD3 Score (three risk groups defined by CD3-IM and CD3-CT): both high-risk, one high-risk, and both low-risk for (A) all with assessments; (B) just those with MMR-proficient, stage II tumors, and no risk factors (T4, poorly differentiated, vascular invasion, or <8^a nodes examined); (C) MMR-proficient, stage II tumors, and one or more risk factors. ^aIn QUASAR, patients with 8-11 lymph nodes examined had similar recurrence risk to those with ≥12 examined and so 8-11 lymph nodes examined were not considered a high-risk characteristic. CT, core tumor; IM, invasive margin; MMR, mismatch repair. Gray et al.²⁸