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. 2024 Sep 24;15:1441944. doi: 10.3389/fimmu.2024.1441944

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Copyright © 2024 Fiore-Gartland, Srivastava, Seese, Day, Penn-Nicholson, Luabeya, Du Plessis, Loxton, Bekker, Diacon, Walzl, Sagawa, Reed, Scriba, Hatherill and Coler

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal expression of modules with changes 7-days post-vaccination. Boxplots of the eigengene expression score for each participant in either the 2-dose or 3-dose “2 + 5” ID93+GLA-SE vaccine group (n=29). (A) MITOSIS module, (B) BCELL module, (C) NEUTRO-II module, (D) COREG module. A line for each participant is overlaid, connecting longitudinal observations. Box extents indicate the interquartile range (IQR) with whiskers indicating the extent of the most extreme observation within1.5-times the IQR.