Table 1.

The information of 9 prognosis MRGs.

Gene	Full name	Location	Function of the encoded protein
DCTPP1	dCTP pyrophosphatase 1	16p11.2	DCTPP1 is an enzyme protein primarily involved in the metabolism of dCTP within cells. Through catalytic hydrolysis reactions, it breaks down dCTP into dCMP and pyrophosphate.
FEZ1	Fasciculation and elongation protein zeta 1	11q24.2	Protein encoded by FEZ1 primarily participates in neuronal development and synapse formation, exerting a crucial role within the nervous system.
KMO	Kynurenine 3-monooxygenase	1q43	KMO plays a crucial role in the kynurenine pathway, which is a metabolic pathway involved in the degradation of the amino acid tryptophan.
NME3	Nucleoside diphosphate kinase 3	16p13.3	NME3 is a protein that belongs to the nucleoside diphosphate kinase family. This family of enzymes plays a crucial role in cellular processes by catalyzing the transfer of phosphate groups between nucleoside diphosphates and nucleoside triphosphates, which are essential for energy transfer and cellular functions.
CCR7	C-C chemokine receptor 7	17q21.2	CCR7 is a protein that belongs to the G-protein coupled receptor family and is involved in mediating cell migration and immune responses. It is specifically known for its role in guiding immune cells to lymph nodes and other secondary lymphoid organs, where immune responses are orchestrated.
ISOC2	Isochorismatase domain containing 2	19q13.42	ISOC2 is a protein that possesses an isochorismatase-like domain, which suggests its potential involvement in certain enzymatic activities related to metabolic processes.
STAR	Steroidogenic acute regulatory protein	8p11.23	STAR is a crucial regulatory protein involved in the synthesis of steroid hormones, which are essential for various physiological processes in the body. The STAR protein facilitates the transport of cholesterol, a precursor molecule, into the mitochondria of steroid-producing cells, where it serves as the building block for steroid hormone production.
COMTD1	Catechol-O-methyltransferase containing domain 1	10q22.2	COMTD1 is a protein that contains a domain similar to catechol-O-methyltransferase, an enzyme involved in the metabolism of catechol compounds, including neurotransmitters like dopamine and catecholamines.
ESR2	Estrogen receptor 2	14q23.2-q23.3	ESR2 refers to Estrogen Receptor β, which is a specific protein in the human body. ESR2 is essential for the functioning of the reproductive system and has effects throughout the body.