Table 3.

The information of 6 metastasis-related MRGs.

Gene	Full name	Location	Function of the encoded protein
PDK4	Pyruvate dehydrogenase kinase 4	7q21.3	PDK4 protein plays a crucial role in the pathway of pyruvate metabolism by inhibiting the activity of pyruvate dehydrogenase through phosphorylation. This inhibition prevents the conversion of pyruvate to acetyl-CoA, thereby influencing the progression of the tricarboxylic acid cycle.
NRF1	Nuclear respiratory factor 1	7q32.2	NRF1 protein is a transcription factor associated with the cellular nuclear respiratory chain. It plays a role in regulating and coordinating mitochondrial biosynthesis, the expression of respiratory chain genes, and overall cellular energy regulation.
DCAF8	DDB1 and CUL4 associated factor 8	1q23.2	DCAF8 protein interacts with the CUL4-DDB1 E3 ligase macromolecular complex, playing a crucial role in biological processes such as cell cycle regulation and DNA damage response.
CHPT1	Choline phosphotransferase 1	12q23.2	CHPT1 is involved in the phosphatidylcholine biosynthetic process and platelet-activating factor biosynthetic process.
MARS2	Methionyl-tRNA synthetase 2	2q33.1	MARS2 protein is a methionyl-tRNA synthetase, primarily responsible for catalyzing the binding of methionine to its corresponding tRNA, forming aminoacyl-tRNA, and participating in the process of mitochondrial protein synthesis within the mitochondria.
NAMPT	Nicotinamide phosphoribosyltransferase	7q22.3	NAMPT protein catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, a step in the biosynthesis of nicotinamide adenine dinucleotide.