Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Sep 24;15:1455462. doi: 10.3389/fmicb.2024.1455462

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Hsu, Saenkham-Huntsinger, Huang, Octaviani, Drelich, Peng and Tseng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Immunohistochemical analysis of SARS-2 antigen in the brain, OE, and TG after infection via the intranasal route. Formalin-fixed, paraffin-embedded (FFPE) skull sagittal or coronal sections containing the brain, OE, and TG were analyzed via immunohistochemistry (IHC) for the expression of the SARS-2 spike (S) protein. SARS-2 S antigen (brown) can be detected only in the OE in one out of five mice (sole positive shown in A) starting from 1 dpi but can begin to be detected in the TG starting from 3 dpi; SARS-2 S could not be detected in all other regions of the brain from 1 dpi to 3 dpi, including the olfactory bulb. Black arrowheads indicate selected points of antigen detection. (A–D) Olfactory epithelium; (E–H) olfactory bulb; (I–L) brainstem (pons); (M–P) trigeminal ganglion. Magnification 40X. Blue nuclei indicate hematoxylin counter-staining.