Figure 7.

SARS-CoV-2 brain infection alters gene expression of neuronal function and neural damage markers. Total RNA extracted from the brains of infected AC70 mice daily after SARS-2 infection were used to measure the gene expression levels of selected neural biomarkers of damage (Nefl and Eno2) and neuronal function (DRD1, TH, Syn-1A, and SNAP-25). Each individual brain sample was assayed in duplicate. Results are shown as means (±SEM) of five animals at each time point. * p < 0.05, ** p < 0.01 (Student’s t-test, compared to mock-infected mice).