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. 2024 Oct 7;15:8613. doi: 10.1038/s41467-024-52216-6

Fig. 6. Intestinal tissue from SBS patients shows increased expression and protein translocation of ZIP4 and ZIP5 to putative sites.

Fig. 6

a Table describes a total of 26 patients that were included in this study. b, c RT-qPCR of tissue derived from human intestinal biopsies. Gene expression levels were normalized by SI expression to estimate expression levels in enterocytes. SLC39A4 (b) is expressed at similar levels in control (n = 14) compared to SBS (n = 12). Approximately 1.5-fold higher SLC39A5 (c) expression in SBS (n = 9) compared to control (n = 12). Data points represent means, and bars represent ±SEM. Mann–Whitney U-test, p = 0.0346. Representative immunostaining of ZIP4 in control (d) and SBS (e) human intestinal tissue biopsies; staining of ZIP5 in control (f) and SBS (g) biopsy tissue demonstrate changes in the localization of zinc transport proteins in response to SBS. Tissue from over 25 biopsies from participants across both the SBS group and the control group were analyzed. Magnification 20×, upper panel scale bar 50 μm; lower panel scale bar 200 μm. Source data are provided as a Source Data file.