Fig. 2.

Spatial protein analysis of inter disease comparison granuloma versus surrounding. (A) Relative protein expression of 72 granulomas (3 granulomas per each of 6 patients per disease group) and the adjacent surrounding. Fold induction threshold was set to 1 (red line), significance threshold at 1.2 (green line) showing uncorrected P-values. Only significantly or borderline significant targets are indicated. (B) Absolute protein counts with median of significant protein expression commonalities in the granulomas of the four diseases. (C) Absolute protein counts with median of protein targets enriched in the granulomas versus the surrounding only in a subset of the volcano plots. (D) Absolute protein counts with median of protein targets enriched in the surrounding versus the granulomas only in a subset of the volcano plots. Statistical differences only indicated for expression in granuloma versus the surrounding per disease, with statistical testing by Mann-Whitney test with * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001