Fig. 3.

Spatial protein analysis in the granulomas of CVID versus granulomas of sarcoidosis, PS and TB. (A) Relative protein expression of 72 granulomas, comparing CVID versus sarcoidosis, or PS or TB, with fold induction threshold set to 1 (red line), significance threshold at 1.2 (green line), showing uncorrected P-values. Only significantly altered or borderline significant targets are indicated. B-D) Absolute protein counts with median of significantly enriched protein differences between CVID versus either (B) sarcoidosis, (C) PS or (D) TB. Statistical testing was performed by Kruskall-Walis with Dunn’s multiple comparison correction, * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001