Table 1.

Histological scoring of granulomas in CVID, sarcoidosis, PS and TB

Histology hallmark	CVID	Sarcoidosis	PS	TB
Original tissue structure affected	2.5 (2–3)	2.5 (2–3)	2 (1–3)	2 (2–3)
Presence of micro granulomas	3***/**/** (2–3)	1 (1–1)	1 (0–2)	0.5 (0–1)
Presence of large granulomas	1****/***/** (0–1)	3 (2–3)	3 (2–3)	3 (2–3)
Clustered granulomas	3 (3–3)	3 (2–3)	2.5 (0–3)	2 (1–3)
Solitary granulomas	1* (0–1)	1.5 (1–3)	2.5 (1–3)	2 (2–3)
Well-circumscribed granulomas	1** (0–2)	3 (2–3)	2 (2–3)	2 (2–3)
Confluent granuloma areas	3* (2–3)	2 (1–3)	1 (0–3)	1.5 (1–3)
Multinucleated giant cells present	0.5 (0–1)	1.5 (1–3)	1 (1–3)	2 (1–3)
Foreign body giant cells	0 (0–0)	0.5 (0–3)	1.5 (0–3)	1 (0–1)
Touton giant cells	0 (0–1)	1 (0–2)	1 (0–2)	1 (0–2)
Langhans giant cells	0.5* (0–3)	3 (1–3)	1.5* (1–3)	3*/* (3–3)
Asteroid body giant cells	0 (0–0)	0 (0–1)	0 (0–3)	0 (0–0)
Lymphocyte infiltration in granuloma	2 (1–2)	1.5 (1–2)	1.5 (1–2)	1 (1–2)
Fibrosis in center of granuloma	0 (0–1)	1** (1–3)	0 (0–1)	1 (1–3)
Fibrosis in adjacent surrounding tissue	0.5** (0–2)	2.5 (1–3)	1 (0–3)	3 (2–3)
Necrotic areas inside granulomas	0 (0–0)	0.5 (0–1)	0 (0–0)	1.5 (0–3)

CVID = Common Variable Immunodeficiency; PS = pseudo sarcoidosis; TB = tuberculosis. Numerical scoring: 0 = not present, 1 = limitedly present, 2 = frequently present, 3 = present throughout slide. A 2way anova, with multiple comparisons test correction using Tukey’s test, comparing the mean of each disease group per histology hallmark was performed; * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001, **** = P ≤ 0.0001