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. 2024 Oct 7;14(1):171. doi: 10.1038/s41408-024-01153-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — A Case HG28 showed a diffuse proliferation of medium-sized lymphocytes with slight pleomorphism, irregular nuclei, and apoptotic bodies consistent with features intermediate between BL and DLBCL (H&E, original magnification at 400×). B MYC break-apart FISH probe showed two colocalizations in each cell consistent with the absence of gene rearrangement. C FISH analysis for 11q-aberration showed 2 green (11q23.3 minimal region gain, MRG), 2 orange (11q24.3 minimal region loss, MRL), and 2 aqua (CEN11 D11Z1) signals, compatible with a non-altered 11q chromosomal region. D Case HG33 depicted a DLBCL morphology showing a predominance of large centroblastic lymphocytes (H&E, original magnification at 400×). E MYC break-apart FISH probe showed one red signal, one green signal, and one colocalization, consistent with the rearrangement of the gene. F FISH analysis for 11q-aberration showed 2 green (11q23.3 MRG), 2 orange (11q24.3 MRL), and 2 aqua (CEN11 D11Z1) signals constellation, compatible with a non-altered 11q chromosomal region. G Case HG39 consisted of monotonous medium-sized lymphocytes with blastoid appearance (H&E, original magnification at 400×). H MYC break-apart FISH probe showed two colocalizations consistent with a non-rearranged pattern. I A non-prototypic terminal deletion of 11q24.3 region was identified in case HG39. The FISH constellation showed 2 green (11q23.3 MRG), 1 orange (22q24.3 MRL), and 2 aqua (CEN11 D11Z1) signals.