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. 2024 Oct 7;14(1):171. doi: 10.1038/s41408-024-01153-0

Fig. 3. Molecular CN and mutational information on 31 B-cell lymphomas with overlapping features between BL and DLBCL.

Fig. 3

A Oncoprint showing gene expression, mutations, and CN characteristics by case. Each column corresponds to a case, the light blue bars in the top histogram depict the number of CNA while the dark blue bars represent the number of driver mutations. Each row of the bottom plot represents a gene. Only genes with driver mutations in more than 2 cases are represented. Asterisks identify significant differences according to adjusted (FDR) Fisher’s exact test (P-adjusted < 0.05). B Diagram of the relative positions of driver mutations is shown for MYC, TP53, CARD11, and NFKBIE genes, x-axes indicate amino acid position. MYC domains (HLH, helix-loop-helix; MYC-LZ, leucine zipper; TAD, transactivation domain). TP53 domains (DBD: DNA-binding domain); TAD: transcription activation domain; CARD11 (CARMA1) domains (CARD, caspase activation, and recruitment domain; PDZ, PDZ containing domain). C Proportion of DZsig positive tumors in the whole analyzed series (n = 27) and according to MYC-R status. D MYC RNA expression (NM_002467.3) according to DZsig and COO categorization and MYC-R status.