Table 2.

Risk prediction models for the primary endpoint of cardiovascular diseases.

	Refit FRS		Refit FRS plus 4-DXA model
	Coefficients (95% CI)	p-value	Coefficients (95% CI)	p-value
Age, years	0.045 (0.017, 0.074)	< 0.005	0.042 (0.014, 0.071)	< 0.005
Men	0.27 (0.093, 0.44)	< 0.005	0.16 (– 0.017, 0.34)	0.076
Total cholesterol (mg/dL)	0.062 (– 0.020, 0.14)	0.14	0.065 (– 0.017, 0.15)	0.12
High-density lipoprotein cholesterol (mg/dL)	– 0.19 (– 0.29, – 0.095)	< 0.001	– 0.17 (– 0.26, – 0.071)	< 0.001
Diabetes	0.49 (0.28, 0.70)	< 0.001	0.43 (0.22, 0.64)	< 0.001
Systolic blood pressure (mm Hg)	0.17 (0.090, 0.25)	< 0.001	0.16 (0.080, 0.24)	< 0.001
Current smoker	0.26 (0.088, 0.60)	< 0.01	0.38 (0.13, 0.64)	< 0.005
4-DXA prognostic index	–		– 0.21 (– 0.30, – 0.13)	< 0.001

All continuous variables were standardized. FRS variables were refitted using a Cox proportional hazards model with and without the 4-DXA prognostic index. FRS Framingham risk score; DXA Dual-energy X-ray absorptiometry; CI confidence interval.