Table 3.

Comparative performance metrics for the FRS model, the 4-DXA model, and the refit FRS plus 4-DXA model.

	Refit FRS	4-DXA model	Refit FRS plus 4-DXA model
C-statistics	0.62 (0.59, 0.65) Reference	0.58 (0.55, 0.61) P = 0.031	0.63 (0.60, 0.66) P = 0.046
Discrimination slope	0.040 (0.029, 0.050)	0.025 (0.017, 0.033)	0.053 (0.041, 0.066)
Quintile	2.53 (1.81, 3.26)	2.02 (1.69, 2.34)	2.84 (2.14, 3.54)
Hosmer-Lemeshow	17.07 P = 0.029	17.28 P = 0.027	11.38 P = 0.18
Integrated discrimination index	1 [Reference]	– 0.015 (– 0.026, – 0.0034) P = 0.011	0.013 (0.0069, 0.019) P < 0.001
Net reclassifcation index	1 [Reference]	– 0.12 (– 0.22, – 0.021); P = 0.018	0.098 (– 0.0033, 0.20) P = 0.058
Event net reclassification index	1 [Reference]	– 0.11 (– 0.19, – 0.020)	– 0.0097 (– 0.093, 0.075)
No-event net reclassification index	1 [Reference]	– 0.015 (– 0.069, 0.037)	0.11 (0.054, 0.16)