Fig. 1.

Differentially expressed genes identified in Dupuytren disease cord fibroblasts compared to paired normal skin wrist fibroblasts. (A) PCA of DD and DDC fibroblasts (triangle is DD, circle DDC). (B) Heatmap showing significant DEGs in DD (pink) vs DDC (cream) fibroblasts. (C) Concept network plot representing the expression of genes from functional categories associated with extracellular matrix. (D). The top 10 significantly enriched GO terms in the biological pathway analysis include extracellular matrix and structure organization. DD is disease cord fibroblasts, DDC are matched wrist skin fibroblasts (Dupuytren Disease Control)(For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)