Fig. 3.

Differentially expressed genes identified in WNT4siRNA fibroblasts compared to normal skin wrist fibroblasts. (A) PCA of WNT4siRNA and NS fibroblasts (triangle is WNT4siRNA, circle NS). (B) Heatmap of significantly differentially expressed genes in WNT4siRNA (pink) vs NS fibroblasts (cream). (C) Concept network plot representing the expression of genes from functional categories associated with extracellular matrix. (D) The top 10 significantly enriched GO terms in the biological pathway category include embryonic skeletal system development. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)