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. 2024 Sep 17;10(18):e38016. doi: 10.1016/j.heliyon.2024.e38016

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© 2024 The Authors. Published by Elsevier Ltd.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Differentially expressed genes identified in WNT4siRNA fibroblasts compared to DDC fibroblasts. (A) PCA of DDC and WNT4siRNA fibroblasts (triangle is WNT4siRNA, circle DDC). (B) Heatmap of significantly differentially expressed genes in DD (blue) vs WNT4siRNA (cream) fibroblasts. (C) Concept network plot representing the expression of genes from functional categories associated with extracellular matrix. The selected genes were identified based on GO analysis. (D) The top 10 significantly enriched GO terms in the biological pathway category include defense response to virus and negative regulation of viral gene replication. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)