Fig. 5.

Differentially expressed genes identified in Dupuytren disease cord fibroblasts and WNT4 siRNA treated normal skin fibroblasts compared to paired normal skin wrist fibroblasts. (A) PCA of the DD and DDC fibroblasts (triangle is DD or WNT4siRNA treated NS fibs, circle normal skin fibroblasts). (B) Heatmap of significantly differentially expressed genes in DD/WNT4 siRNA vs NS fibroblasts. (C) Concept network plot representing the expression of genes from functional categories associated with organ development. (D) GO analysis identified over-representative GO terms for the DEGs in treated fibroblasts. The top 10 significantly enriched GO terms in the biological pathway category include embryonic organ development.