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. 2024 Jul 19;18(10):2356–2368. doi: 10.1002/1878-0261.13698

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© 2024 The Author(s). Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Histologic features and HER2 immunohistochemical analysis of ERBB2‐mutated endometrial carcinomas. (A) Stratification of ERBB2‐mutated endometrial carcinomas by HER2 immunohistochemistry (IHC) score (n = 41). HER2 IHC scores, and other tumor characteristics are color‐coded according to the legend. CN‐H/TP53abn, copy number‐high/TP53 abnormal; CN‐L/NSMP, copy number‐low/no specific molecular profile; high‐grade EC‐NOS, high‐grade endometrial carcinoma, not otherwise specified; MSI‐H, microsatellite instability‐high. (B) Photomicrographs of representative cases (H&E and HER2 IHC): EC52, endometrioid carcinoma, Grade 1 (100× magnification); EC56, clear cell carcinoma (200× magnification); EC51, high‐grade EC‐NOS (100× magnification); EC67, serous carcinoma (ERBB2‐mutated and amplified, 100× magnification). Scale bar represents 100 μm.