Table 2. Three-way ANOVA for the final irrigation activation system, intracanal medicament, root canal region, and the interaction terms according to the maximum penetration depth .

Source of variation	Type III sum of squares	SD	Mean square	F	Sig.
Final irrigation activation system	11849601.9	3	3949867.3	30.326	< 0.001
Intracanal medicament	544.7	1	544.7	0.004	0.948
Root canal region	8757363	2	4378681.5	33.619	< 0.001
Final irrigation activation system * Intracanal medicament	433693.4	3	144564.5	1.11	0.346
Final irrigation activation system * Root canal third	247795.7	6	41299.3	0.317	0.928
Intracanal medicament * Root canal region	1365641.1	2	682820.5	5.243	0.006
Final irrigation activation system * Intracanal medicament* Root canal region	608365.4	6	101394.2	0.778	0.587

Statistically significant difference at P < 0.05.