Fig. 8.

De novo mutations in VISTA elements near human NR2F1. VISTA regulatory elements (purple) and genes (blue) in the genomic region around NR2F1 are shown at the bottom. PhyloP conservation scores for the region based on 100-way vertebrate analysis are shown under the genes. Three inserts show the location of seven de novo mutations observed in 8,626 ASD cases (red) and 4,461 sibling controls (blue). Labels show the sample size, genomic position of the first nucleotide, and the nucleotide change (VCF format).