Skip to main content
. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Nat Metab. 2024 Apr 15;6(5):825–836. doi: 10.1038/s42255-024-01029-4

Extended Data Figure 6. Hepatic dKO of NCOR1 and 2 in female mice.

Extended Data Figure 6.

a, Body weight and b, liver weight of female control and dKO mice 5 and 15 days post dKO. Biological replicates include: Control day 5 (n=4 mice), dKO day 5 (n=5 mice), Control day 15 (n=5 mice), dKO day 15 (n=5 mice). P-values calculated by two-tailed unpaired students t-test: day 5 p=.0048, day 15 p<.0001. c, RT-qPCR of lipogenic genes (n=4 mice). P-values calculated by unpaired, two-tailed students t-test. d, Hepatic TG levels (n=4-5 mice). P-values calculated by unpaired, two-tailed students t-test e, Glucose metabolism genes in female dKO mice (n=4 mice). P-values calculated by unpaired, two-tailed students t-test. f, Glucose levels throughout a 24 hour fast in female control and dKO mice (n=5 mice per group). P-values calculated by RM two-way ANOVA with Šídák’s multiple comparisons test: ZT8 p=.0004, ZT12 p=.0001. g, IP-Alanine Tolerance Test in Vehicle Treated (-Saline n=3) or Alanine Treated (-Ala) female mice, (n=8 control mice and 4 dKO mice). P-values were calculated by RM two-way ANOVA (Control:dKO p=.0135, Control:Saline p=.0001). For all panels, biological replicates are plotted as mean +/− S.E.M. p<.05*, p<.01**, p<.001***, p<.0001****.