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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Nat Metab. 2024 Apr 15;6(5):825–836. doi: 10.1038/s42255-024-01029-4

Extended Data Figure 5: NCORs are required for the hepatic fasting response.

Extended Data Figure 5:

a, Liver glycogen levels in animals either fasted for 24 hours (Fasted) or fasted for 24 hours followed by a 3-hour Re-feed (Refed). Refed Control vs Refed dKO (p=.0302) b, Serum Beta-hydroxy Butyrate levels (βHB). d, RT-qPCR of Ketogenic markers and f, Fatty Acid Oxidation markers relative to 36b4. e, Hepatic free fatty acids (FFA). f,g, RT-qPCR of glucoregulatory genes relative to 36b4. RT-qPCR data represented as fold change relative to Control-Refed animals. For all panels, biological replicates are plotted (n=3-4 mice) as mean +/− S.E.M. and p-values were calculated by two-way ANOVA with Turkey’s multiple comparisons test. Panel e: Pdk4 (fasted p=.003), Panel f: Ldha (fasted p<.0001, fed p=.0041), Slc38a2 (fasted p=.0007), Slc38a3 (fasted p<.0001), Gpt (fasted p=.0007, fed p=.0366), Got2 (fasted p=.0003, fed p=.0178), Gls2 (fasted p<.0001, fed p=.0003), Slc2a2 (fasted p<.0001, fed p=.0008), Slc37a4 (fasted p=.0245). p<.05*, p<.01**, p<.001***, p<.0001****.