Table 1. Clinical Characteristics of the Patients Treated With Directly Isolated Allogeneic Virus–Specific (DIAVIS) T Cells.
| Patient No. | Age at DIAVIS T-cell transfer | Sex | Underlying cause of PML | Category of underlying cause | Initial clinical deficits | mRS at DIAVIS T-cell transfer | Leading clinical deficits | No. of T-cell infusions | 12-mo Survival | Time of death after first T-cell therapy, d |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Mid-50s | F | Hodgkin disease, lung transplantation | Lympho proliferative |
Disorientation, visual disturbances, headache, nausea | 5 | Quadriplegia, dysarthria, reduction of vigilance being bedridden | 4 | Alive | NA |
| 2 | Early 70s | F | Dermatomyositis, breast cancer | Autoimmune disease | Gait disturbance | 5 | Cerebellar syndrome being dependent on wheelchair, dysarthria, dysphagia with PEG-placement | 4 | Alive | NA |
| 3 | Mid 70s | M | Chronic lymphocytic leukemia | Lympho proliferative |
Cognitive impairment | 3 | Left-sided hemiparesis being bedridden, dysphagia, cognitive impairment | 1 | Death due to PML | 26 |
| 4 | Mid 40s | M | Crohn disease | Autoimmune disease | Dysarthria, left-sided brachiofacial hemiparesis, headache, psychomotor deceleration | 5 | Reduction of vigilance being bedridden, dysarthria, left-sided brachiofacial hemiparesis, neglect left | 3 | Alive | NA |
| 5 | Mid 40s | M | Sarcoidosis | Autoimmune disease | Hypesthesia left hand, left-sided facial impairment | 4 | Left-sided spastic brachiofacial hemiparesis being bedridden, neglect left, cognitive impairment | 3 | Alive | NA |
| 6 | Early 80s | M | Chronic lymphocytic leukemia | Lympho proliferative |
Cognitive impairment | 3 | Left-sided spastic brachiofacial hemiparesis being bedridden, neglect left, cognitive impairment | 2 | Death due to PML | 43 |
| 7 | Early 40s | M | Lymphopenia without preceding immunotherapy | Lymphopenia | Cognitive impairment, change of character, dysarthria | 5 | Reduction of vigilance in need of intensive care, quadriplegia | 3 | Alive | NA |
| 8 | Mid 50s | M | Lymphopenia without preceding immunotherapy | Lymphopenia | Dysarthria, left-sided facial impairment | 2 | Dysarthria, left-sided facial impairment, right-sided spastic arm paresis, spastic paraparesis | 3 | Alive | NA |
| 9 | Late 60s | M | Follicular lymphoma | Lympho proliferative |
Aphasia | 3 | Dysarthria, aphasia, right-sided brachiofacial hemiparesis, right-sided hemihypesthesia, reduction of vigilance being bedridden | 4 | Death due to PML | 139 |
| 10 | Mid 50s | M | Pre-B acute lymphoblastic leukemia | Lympho proliferative |
Right-sided arm paresis | 5 | Organic psychosyndrome being bedridden, right-dominant tetraparesis, dysarthria | 3 | Alive | NA |
| 11 | Mid 60s | M | Chronic lymphocytic leukemia | Lympho proliferative |
Hypesthesia left hand | 5 | Organic psychosyndrome, severe reduction of vigilance being bedridden, spastic quadriplegia | 2 | Death due to PML | 46 |
| 12 | Early 50s | M | HIV infection | AIDS | Epileptic seizure | 1 | Epileptic seizures, tetraataxia, bradydysdiadochokinesa right arm | 3 | Alive | NA |
| 13 | Early 70s | M | Chronic lymphocytic leukemia | Lympho proliferative |
Coordination disorder, dysarthria | 3 | Psychomotor deceleration, left-sided hemiparesis, neglect left | 2 | Alive | NA |
| 14 | Early 60s | M | Chronic lymphocytic leukemia | Lympho proliferative |
Visual disturbances | 5 | Cortical blindness, reduction of vigilance being bedridden, apraxia, dysarthria, cognitive impairment, dysphagia with PEG and tracheotomy placement | 3 | Alive | NA |
| 15 | Early 60s | M | Diffuse large B-cell lymphoma | Lympho proliferative |
Aphasia, confusion | 3 | Sensomotoric aphasia, apraxia, left-sided hemiparesis | 3 | Death due to PML | 203 |
| 16 | Late 70s | M | Diffuse large B-cell lymphoma | Lympho proliferative |
Fine motor dysfunction of right hand, latent right-sided leg paresis | 4 | Right-sided hemiparesis, right-sided hemihypesthesia, gait ataxia, motor aphasia | 2 | Alive | NA |
| 17 | Late 50s | F | Early T acute lymphoblastic leukemia | Lympho proliferative |
Left-sided leg paresis | 4 | Left-sided brachiofacial hemiparesis being bedridden, psychomotor deceleration | 3 | Alive | NA |
| 18 | Mid 50s | M | HIV infection | AIDS | Gait disturbance | 4 | Right-sided hemiparesis, visual disturbance, ataxia, motor aphasia | 3 | Alive | NA |
| 19 | Early 80s | M | Chronic lymphocytic leukemia | Lympho proliferative |
Aphasia | 5 | Right-sided hemiplegia being bedridden, neglect right, aphasia | 3 | Death due to PML | 72 |
| 20 | Late 50s | M | Multiple myeloma | Lympho proliferative |
Left-sided arm paresis, hypesthesia left arm | 4 | Left-sided hemiparesis being dependent on wheelchair, left-sided hemihypesthesia, neglect left | 2 | Alive | NA |
| 21 | Early 80s | M | Kidney failure, dialysis-dependent | Lymphopenia | Cognitive impairment, left-sided hemiparesis, reduction of general condition | 5 | Cognitive impairment, left-sided hemiparesis being bedridden | 2 | Death due to COVID-19 | 155 |
| 22 | Early 30s | M | Acute lymphoblastic leukemia | Lympho proliferative |
Right-sided leg paresis | 4 | Left-sided hemiparesis being dependent on wheelchair | 3 | Alive | NA |
| 23 | Early 80s | F | Rheumatoid arthritis | Autoimmune disease | Disorientation, change of character | 5 | Reduction of vigilance, left-sided hemiparesis being bedridden, neglect left | 3 | Death due to age | 222 |
| 24 | Early 40s | F | Hodgkin lymphoma, diffuse large B-cell lymphoma | Lympho proliferative |
Headache | 3 | Cephalgia, bilateral visual reduction, left-sided homonymous hemianopsia, cognitive impairment | 3 | Alive | NA |
| 25 | Late 60s | F | Follicular lymphoma | Lympho proliferative |
Cognitive impairment | 4 | Aphasia, cognitive impairment, right-sided hemiparesis | 2 | Alive | NA |
| 26 | Early 70s | F | Cutaneous polyarteritis nodosa | Autoimmune disease | Aphasia, left-sided arm paresis, left-sided hemihypesthesia, neglect left | 3 | Aphasia, apraxia, organic psychosyndrome, left-sided arm paresis, left-sided hemihypesthesia, neglect left | 3 | Alive | NA |
| 27 | Mid 60s | F | Follicular lymphoma | Lympho proliferative |
Headache, visual disturbance, gait disturbance, dizziness |
2 | Gait ataxia, hypermetric saccades, depressive episode | 3 | Alive | NA |
| 28 | Late 30s | M | Severe combined immunodeficiency | Lymphopenia | Aphasia | 3 | Motor aphasia, apraxia | 3 | Alive | NA |
Abbreviations: mRS, modified Rankin Scale; NA, not applicable; PEG, percutaneous endoscopic gastrostomy; PML, progressive multifocal leukoencephalopathy.