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. 2024 Oct 8;6(4):lqae139. doi: 10.1093/nargab/lqae139

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© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Synthetic data showing bifurcation and branching models. (A) Bifurcation as a model of cell-fate decision. Bi-potential progenitor cells (black) proceed to a decision point after which they proceed in one of two new directions in gene expression space. (B) A simplified version of branching behaviour as a model of cell-fate decision. Here bi-potential cells proceed along a default developmental pathway to one of their potential outcomes. The decision is whether or not to leave this default pathway and develop in a new direction. (C) In this version of branching behaviour, there is a region rather than a single point at which cells choose to leave the default pathway.