FIG. 1.
Cases where autologous neutralizing-antibody levels correlated with viremia control following treatment interruption. The HIV-1 RNA level in plasma was measured at closely spaced intervals, usually every 3 to 7 days, during the periods of treatment and treatment interruption. Neutralizing-antibody levels were measured at various intervals while the subjects remained off therapy. Intervals when the subjects were on therapy are shaded. Plasma HIV-1 RNA levels (copies per milliliter) are shown as open circles, where a value of 5,000 is indicated by a horizontal dashed line. Titers of neutralizing antibodies are shown as solid circles (autologous virus), solid squares (HIV-1MN), and solid triangles (HIV-1IIIB). Titers of neutralizing antibodies that were below the limit of detection (<1:4 for autologous viruses and <1:20 for HIV-1MN and HIV-1IIIB) were assigned a value of 2. It should be noted that neutralization assays were performed with all viruses for each plasma sample, such that negative values at early time points overlap in the figure.